Varisync NanoPrime ALIF cage with anchors
FLOWOOD, Mississippi, Nov. 14, 2025 /PRNewswire/ — Zavation Medical Products, LLC (“Zavation”), a leading innovator in spinal device technology, proudly announces the launch of NanoPrime™, a next-generation implant material that combines the mechanical advantages of PEEK with the biological benefits of titanium through advanced titanium ion bonding technology.
NanoPrime™ uses a cutting-edge nanoengineering process involving evaporation and ion beam bombardment in a high vacuum environment. This technique allows the atoms of the coating and the substrate to join together on a surface, minimizing the risk of delamination.
NanoPrime™ technology will debut with Zavation’s Varisync® ALIF interbody system and will serve as an embedded platform technology across the entire Labyrinth® Porous PEEK interbody offering. Zavation believes this will be the first titanium porous PEEK interbody with nanoscale features, truly offering the best attributes of titanium, porosity and PEEK in a single interbody technology.
Labyrinth Nanoprime cervical cage
NanoPrime™ perfectly integrates these advantages and offers:
Biological compatibility and osteoconductivity of titanium 2, 3 PEEK elastic modulus and image compatibility 4, 5 A surface with nanoscale-level features and average surface roughness measurements between 0.104 μm and 0.303 μm, which can support the positive regulation of osteoblast-derived angiogenic factors and osteogenic markers 1, 2 Micro and macro porosity combined with Labyrinth® porous PEEK technology 1
Lane Major, CEO of Zavation, said: “NanoPrime™ marks a major step forward in how we combine materials science with practical implant design. It represents what we believe is the first family of macro, micro and nano porous PEEK-Ti bonded spinal implants, offering a level of differentiation rare in our industry and critical to our commitment to supporting surgeons and the patients they serve.”
Zavation remains committed to advancing spinal device technology and developing material solutions that support more robust and predictable surgical outcomes. To learn more about the Varisync® ALIF NanoPrime™ Interbody System and Zavation’s complete portfolio of spinal solutions, visit us at NASS Booth #1621.
About Zavation
Zavation is a rapidly growing designer and manufacturer of biologics and spinal devices based in Flowood, Mississippi. Focused on innovation, surgeon collaboration and superior customer care, Zavation delivers advanced spinal solutions that improve surgical outcomes and patient quality of life.
References
Williamson, S. and A. Parekh. Surface Characterization of ALIF and PLIF Cages. Data on file, Department of Biomedical Materials Science, School of Dentistry, University of Mississippi Medical Center, 2024. Olivares-Navarrete, R., et al. “Implant materials generate different peri-implant inflammatory factors: PEEK promotes fibrosis and microtextured Ti promotes osteogenic factors.” Vertebral column, vol. 40, no. 6; 2015, pp. 399–404. Olivares-Navarrete, R., et al. “Unwrought titanium alloys regulate the production of angiogenic factors in osteoblasts.” Spine Journal, Vol. 13, no. 11; November 2013. Cabraja, M., et al. “Anterior cervical discectomy and fusion: comparison of titanium and polyetheretherketone cages”. BMC Musculoskeletal Disorders, Vol. 13, no. 172, 2012. Warburton, A., et al. “Biomaterials in spinal implants: a review.” Neuroespina, vol. 17, no. 1, March 2020, pp. 101-110.
Zavation®, NanoPrime™ and Varisync® are registered trademarks of Zavation Medical Products, LLC
SOURCE Zavation Medical Products, LLC.
