Varisync ALIF construction with NanoPrime cage
FLOWOOD, Mississippi, Nov. 15, 2025 /PRNewswire/ — Zavation Medical Products, LLC (“Zavation”), a leading innovator in spinal device technology, announces the first successful implantations of the Varisync® ALIF NanoPrime™ System, a next-generation standalone ALIF system featuring Zavation’s patented titanium ion bonding technology.
NanoPrime™ combines the mechanical advantages of PEEK with the biological benefits of titanium, providing improved radiographic visualization, biomechanical compatibility5 and fusion potential1, 2, 3, 4.
Dr. Steve Zhou successfully performed a two-level anterior lumbar fusion using NanoPrime™ ALIF to treat a patient with L4-L5 Grade 1 spondylolisthesis and severe L5-S1 spondylosis. Postoperatively, the patient reported improvement in symptoms.
Dr. Steve Zhou
“The NanoPrime™ ALIF cage offered excellent radiographic visibility and the potential to generate positive surgical outcomes,” said Dr. Steve Zhou. “Its softer modulus compared to pure titanium reduces the risk of subsidence, while the bonded surface of the titanium promotes solid fusion and eliminates my concerns about fibrous bonding.”
Dr. Zhou, a fellowship-trained orthopedic spine surgeon at Orthopedic Associates of Hartford, is recognized for his patient-centered approach and expertise in advanced spinal procedures. His clinical experience highlights the real-world benefits of NanoPrime design to improve visualization, biomechanical compatibility, and overall patient outcomes.
Lane Major, CEO of Zavation, said: “Varisync® ALIF NanoPrime™ reflects our commitment to bringing truly differentiated technology to spine surgery. This system combines thoughtful design with advanced materials science, providing surgeons with a streamlined and versatile option in the anterior space. It is the type of innovation that reinforces our mission to elevate patient care and support the clinical needs of our partners.”
To learn more about the Varisync® ALIF NanoPrime™ Interbody System and Zavation’s complete portfolio of spinal solutions, visit us at NASS Booth #1621.
About Zavation
Zavation is a rapidly growing designer and manufacturer of biologics and spinal devices based in Flowood, Mississippi. Focused on innovation, surgeon collaboration and superior customer care, Zavation delivers advanced spinal solutions that improve surgical outcomes and patient quality of life.
References
Williamson, S. and A. Parekh. Surface Characterization of ALIF and PLIF Cages. Data on file, Department of Biomedical Materials Science, School of Dentistry, University of Mississippi Medical Center, 2024. Olivares-Navarrete, R., et al. “Implant materials generate different peri-implant inflammatory factors: PEEK promotes fibrosis and microtextured Ti promotes osteogenic factors.” Vertebral column, vol. 40, no. 6; 2015, pp. 399–404. Olivares-Navarrete, R., et al. “Unwrought titanium alloys regulate the production of angiogenic factors in osteoblasts.” Spine Journal, Vol. 13, no. 11; November 2013. Cabraja, M., et al. “Anterior cervical discectomy and fusion: comparison of titanium and polyetheretherketone cages”. BMC Musculoskeletal Disorders, Vol. 13, no. 172, 2012. Warburton, A., et al. “Biomaterials in spinal implants: a review.” Neuroespina, vol. 17, no. 1, March 2020, pp. 101-110.
Zavation®, NanoPrime™ and Varisync® are registered trademarks of Zavation Medical Products, LLC
SOURCE Zavation Medical Products, LLC.
