Abstract: Researchers have discovered that antioxidants from Ecklonia cava, a sort of seaweed, might assist stop Parkinson’s illness by defending dopamine-producing neurons. In mouse fashions, these antioxidants restored motor perform and improved intestine well being after publicity to toxins.
Mobile research revealed that these compounds activate the AMPK enzyme and cut back dangerous reactive oxygen species, doubtlessly providing a brand new method to fight neurodegeneration. This discovery highlights the potential of Ecklonia cava as a preventive ingredient towards Parkinson’s illness.
Key Details:
- Ecklonia cava Antioxidants: Seaweed polyphenols from Ecklonia cava have been proven to enhance motor perform and intestine well being in Parkinson’s illness mannequin mice.
- Mechanism of Motion: The antioxidants activate AMPK, an important enzyme, and inhibit the manufacturing of reactive oxygen species that harm neurons.
- Potential Remedy: This analysis suggests a promising pure method to stopping Parkinson’s illness, which at the moment lacks healing remedies.
Supply: Osaka Metropolitan College
Parkinson’s illness is a neurodegenerative illness brought on by the lack of neurons that produce dopamine, a neurotransmitter concerned in motor management and cognitive perform.
As the worldwide inhabitants ages, the variety of Parkinson’s illness sufferers is quickly rising. Parkinson’s illness is induced by neuronal harm as a consequence of extreme manufacturing of reactive oxygen species.
Suppression of reactive oxygen species era is important as a result of it’s deadly to dopaminergic neurons that handle dopamine neurotransmitters. At the moment, solely symptomatic remedy is accessible, so the event of remedy regimens and prevention strategies is important.
Thankfully, Affiliate Professor Akiko Kojima-Yuasa of Osaka Metropolitan College’s Graduate College of Human Life and Ecology led a analysis group that has verified the physiological impact of Ecklonia cava polyphenols, seaweed antioxidants, on the prevention of Parkinson’s illness.
On this research, two varieties of motor perform assessments have been carried out utilizing Parkinson’s illness mannequin mice that have been orally fed the antioxidants day by day for one week after which administered rotenone.
Outcomes confirmed that motor perform, which was decreased by rotenone, was restored. There was additionally enchancment in intestinal motor perform and the colon mucosa construction, a particular tissue that covers the colon.
Additional, mobile experiments utilizing Parkinson’s illness mannequin cells verified the biochemical interplay of the preventive impact of Ecklonia cava. Validation outcomes confirmed that the antioxidants activate the AMPK enzyme (adenosine monophosphate-activated protein kinase), an intracellular vitality sensor, and inhibit the manufacturing of reactive oxygen species that trigger neuronal cell dying.
“This research means that Ecklonia cava antioxidants might cut back neuronal harm by AMPK activation and inhibiting intracellular reactive oxygen species manufacturing,” said Professor Kojima-Yuasa. “It’s hoped that Ecklonia cava will likely be an efficient ingredient within the prevention of Parkinson’s illness.”
About this Parkinson’s illness analysis information
Writer: Yung-Hsiang Kao
Supply: Osaka Metropolitan College
Contact:Yung-Hsiang Kao – Osaka Metropolitan College
Picture: The picture is credited to Neuroscience Information
Unique Analysis: Open entry.
“Ecklonia cava Polyphenols Have a Preventive Impact on Parkinson’s Illness by way of the Activation of the Nrf2-ARE Pathway” by Akiko Kojima-Yuasa. Vitamins
Summary
Ecklonia cava Polyphenols Have a Preventive Impact on Parkinson’s Illness by way of the Activation of the Nrf2-ARE Pathway
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