Ozempic and Wegovy may provide help to shed undesirable kilos and preserve obesity-related illness at bay — however you would lose some muscle within the course of, some consultants warn.
Speedy weight reduction can lead to a situation referred to as sarcopenia, outlined as “the gradual lack of muscle mass, power and performance,” in keeping with Healthline — however there are steps you possibly can take to scale back the danger whereas nonetheless sustaining a wholesome weight.
Semaglutide medicines similar to Ozempic and Wegovy trigger weight reduction via a mixture of mechanisms, together with delayed gastric emptying and the GLP1 hormones that sign the abdomen to really feel full, famous Andrew Y. Solar, M.D., a board-certified urologist and chief medical advisor for Marius Prescribed drugs in Dallas-Ft. Price, Texas.
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“Each of those lead to a caloric restriction that causes weight reduction,” he informed Fox Information Digital.
When folks shed kilos, it ends in a mixture of each fats loss and muscle loss.
“Within the scientific research for medicine within the GLP1 class, the information indicated that 40% to 50% of the load loss comes from lean muscle mass as an alternative of fats,” Solar stated. “While you lose muscle mass, your resting metabolic price, or the speed the physique burns energy, additionally declines.”
Dr. Brett Osborn, a Florida neurologist and longevity skilled, shared methods for preserving muscle mass whereas taking weight-loss medicines. “Our muscle is our resilience,” he stated. (Dr. Brett Osborn)
Whereas all sufferers are vulnerable to the loss in muscle mass, ladies are likely to lose greater than males, famous Dr. Brett Osborn, a Florida neurologist, longevity skilled and bodybuilder.
“One of many main components has to do with circulating testosterone ranges,” he informed Fox Information Digital.
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“Ladies have decrease ranges naturally and have lesser muscle mass at base stage. In a caloric deficit, testosterone ranges additional lower, and there may be potential for vital muscle loss (sarcopenia). This equally happens within the aged inhabitants.”
‘Extra vulnerable to falls’
The well being results of shedding muscle will be extra harmful for sure sufferers than others, Solar famous.
“While you lose muscle or when you could have inadequate quantities of muscle tissue, you’re extra vulnerable to falls and fractures,” he warned.
Stopping muscle loss begins with heightened surveillance from each the affected person and the doctor, a health care provider informed Fox Information Digital. (iStock)
“It makes restoration from sickness and injury tougher and, normally, results in frailty and a extra sedentary life-style that may, in excessive instances, improve the probability of demise.”
Older sufferers are significantly in danger, he stated, however all adults begin shedding muscle mass as a pure a part of the ageing course of.
“This begins as early as your 30s and 40s, selecting up considerably as adults method 65,” Solar stated. “Some recommend that adults might lose as much as 8% of muscle mass every decade.”
“While you lose muscle or when you could have inadequate quantities of muscle tissue, you’re extra vulnerable to falls and fractures.”
Then, “whenever you take a semaglutide drug like Ozempic, Wegovy or Mounjaro, you’re considerably rising this muscle loss — and that may be regarding in case you’re an at-risk affected person.”
Osborn emphasised the significance of muscle as a protector from illness.
“Our muscle is our resilience,” he stated. “Along with being aesthetically pleasing, muscle tissue serves as a protein depot from which antibodies type, permitting us to fend off pathogens.”
One approach to stimulate urge for food is thru power coaching, which additionally helps to mood muscle loss. “Muscle is crucial to your well being,” stated one doctor. (iStock)
Muscle additionally acts as a “glucose filter,” he famous, which helps to manage blood sugar and reduces the danger of coronary heart illness and diabetes.
“The much less muscle you could have, the extra vulnerable you’re to those illnesses — so, muscle is crucial to your well being.”
‘Pay shut consideration’
Folks can take sure steps to counter the danger of semaglutide-related muscle loss, consultants agree.
“It begins with heightened surveillance from each the affected person and the doctor,” Osborn informed Fox Information Digital.
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He recommends that physicians conduct common physique measurements of sufferers and alter the remedy dosage if benchmarks are usually not being met.
“Sufferers must pay shut consideration to their waistlines and their muscle mass relative to their complete physique weight,” stated Osborn. “A male’s physique weight ideally must be comprised of fifty% muscle and a feminine’s must be 45%.”
Attaining that ratio will assist stave off age-related illnesses similar to coronary artery illness, sort 2 diabetes, most cancers and Alzheimer’s, the physician stated.
In some instances, docs might prescribe hormone remedy to help a person’s muscle mass. (Rory Doyle for The Washington Put up through Getty Pictures)
“It would additionally shield you from frailty and the related lack of mobility that place you at a excessive fall danger, which is a significant reason for morbidity and mortality in folks over the age of fifty,” he stated.
It’s additionally crucial that each affected person makes an attempt to satisfy their prescribed every day energy, Osborn stated.
“The much less muscle you could have, the extra vulnerable you’re to illnesses — so, muscle is crucial to your well being.”
“In my clinic, we shoot for a caloric consumption equal to at least one’s sedentary basal metabolic price, or BMR,” he stated. “We enable the remedy to create a slight caloric deficit to help in weight reduction, however we don’t advocate that sufferers starve themselves, as is usually seen within the media.”
One approach to stimulate urge for food is thru power coaching, Osborn famous, which additionally helps to mood muscle loss.
Solar agreed that sufferers on semaglutide remedy ought to undertake power and resistance coaching — mixed with a high-protein weight loss plan — to offset the consequences of muscle loss.
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In some instances, Osborn additionally prescribes hormone alternative remedy to help a person’s muscle mass.
“Utilizing this protocol, we will keep muscle regardless of Ozempic utilization whereas driving fats loss, which is a double bonus — and actually one of the best of each worlds,” he stated.
“Along with being aesthetically pleasing, muscle tissue serves as a protein depot from which antibodies type, permitting us to fend off pathogens,” a health care provider stated. (iStock)
Trying forward, Solar stated he hopes that the subsequent technology of weight-loss medicine can be extra targeted on balanced physique composition somewhat than fats loss.
“Till then, there are circumstances the place muscle loss ought to immediate conversations between the doctor and affected person about life-style modifications and concomitant use of different medicine like testosterone to take care of muscle mass,” he added.
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Fox Information Digital reached out to Novo Nordisk, the producer of Ozempic and Wegovy, requesting touch upon the remedy’s potential to extend muscle loss.
For extra Health articles, go to www.foxnews.com/well being.