Summary: A new study highlights the link between intestinal health and subsequent COVID (PCs) syndrome, revealing that patients with previous gastrointestinal problems are more likely to experience post-viral fatigue. The researchers analyzed samples of patients with PC and identified key immune and intestinal biomarkers linked to inflammation and dysfunction of the intestinal barrier.
In particular, altered IL-6 levels and a higher LBP/SCD14 relationship suggest chronic immune activation in PC patients. These findings suggest that intestinal monitoring can be vital to predict and manage subsequent symptoms to the long -term COVID.
Key facts:
Immune changes: PCs with PCs showed an increase in inflammatory markers such as IL-6 and a high LBP/SCD14 relationship.
Source: Vienna Medicine University
In a recent study, a research team from the University of Medicine of Vienna has acquired new knowledge about the Syndrome after COVEL (PCs) and the relevance of a healthy gastrointestinal tract.
The study, which was recently published in Allergy magazine, shows that PCs have altered inflammatory markers and a disturbed intestinal barrier, which could contribute to the development of post-viral fatigue.
The researchers, led by Eva UNTERSMAYR-ELENHUBER of the Center for Pathophysiology, Infectiology and Immunology of Meduni Vienna, analyzed the data of a prospective observational study.
The course of SARS-COV-2 infections and gastrointestinal symptoms before, during and after infection were examined. In addition, blood, saliva and feces of patients with PCs were analyzed.
The results show that patients with pre -existing gastrointestinal complaints have a greater risk of developing PC fatigue. At the same time, prominent changes were found in certain biomarkers.
For example, patients with PCs showed a greater LBP/SCD14 ratio and lower levels of IL-33, indicating an altered immune activation and a reduced intestinal barrier. In addition, there was an increase in IL-6 levels, which are considered a marker for systemic inflammatory reactions.
“Our results suggest that SARS-COV-2 infection can have long-term effects on the immune system and intestinal health that contribute to the development of PCs,” explains Eva Untersmayr-Elenhuber. She is co -director of the National Reference Center for Postviral Syndromes in Meduni Vienna.
Development of specific treatment strategies
The study underlines the central role of the gastrointestinal tract in the development of long-term consequences after COVID-19. Gastrointestinal symptoms monitoring and biomarkers could help identify patients at risk at an early stage and develop specific treatment strategies. This could be particularly important for the treatment of post-viral fatigue.
“What is particularly exciting is that the participants of our study were mostly young and healthy before infection. Even Covid disease was mostly mild or even asymptomatic.
“A difference was the most frequent gastrointestinal complaints in the group that developed post-viral fatigue,” explains Johanna Rohrhofer at the center of Pathophysiology Infectiology and Immunology, main author of the study.
The research team plans to validate the findings in more studies. “The identification of predictive markers for PC could allow customized prevention and treatment in the future,” says Eva Untersmayr-Elenhuber.
About this publication news of Fatiga Covid
Author: Karin Kirschbichler
Source: Vienna Medicine University
Contact: Karin Kirschbichler – University of Medicine of Vienna
Image: The image is accredited to Neuroscience News
Original research: open access.
“Interruption of the gastrointestinal barrier in patients with fatigue of the Syndrome after Covid” by Eva Untersmayr-Elenhuber et al. Allergy
Abstract
Interruption of the gastrointestinal barrier in patients with fatigue of the Syndrome after covid
Background
Covid (PCS) syndrome is the term for a condition with persistent symptoms in a proportion of patients with COVID-19 after asymptomatic, slight or severe disease courses. The numbers vary, but the current estimate is that after COVID-19 approximately 10% develop PC.
The objective of our study was to evaluate the impact of SARS-COV-2 infection on the gastrointestinal tract (GI) and associations with the development of PC with fatigue, discomfort postsertion (PEM), orthostatic deregulation, autonomous deregulation and neurocognitive deregulation.
Methods
When combining medical record data of a prospective observational study with symptom analysis before, during and after SARS-COV-2 infection, our goal was to identify possible risk factors and predictive markers for PCs. In addition, we analyze samples of blood, saliva and feces of this cohort of PCs well characterized to biologically validate our findings.
Results
We identify significant associations between pre -existing GI complaints and the development of PCs fatigue. PCs with PCs showed higher LBP/SCD14 relationships, lower levels of IL-33 and higher levels of IL-6 compared to control groups. Our results highlight the critical role of the gastrointestinal tract in the development of PCs of post-viral fatigue.
Conclusion
We propose that the viral infection interrupts the roads related to the innate immune response and the function of Barrera GI, evidenced by low -degree intestinal inflammation and the escape of Barrera Gi. Monitoring the symptoms and markers GI before, during and after the SARS-COV-2 infection is crucial to identify predictive clinical phenotypes on PC.
Understanding the interaction between viral infections, immune responses and intestinal integrity could lead to more effective diagnostic and treatment strategies, ultimately reducing the load for patients with PCs.
