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    NIH grants support Kessler Foundation scientists to advance research on neglect dyslexia and autism

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    Two more universities set to join IUCRC BRAIN at University of Houston to advance neurotechnology

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    New review looks at the impact of robotic exoskeletons on recovery of ambulation among individuals with acquired brain injury

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    Kessler Foundation researchers receive $1.7 million in grants to improve lives of TBI patients

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    Novel tool could help neuroscientists crack the secrets of spinal cord

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    Boost brain health and slow mental aging with 10 intriguing tips from longevity experts

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    Ask a doc: ‘How can I make vaccinations and blood draws less scary for my child?’

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    COVID vaccine just approved should be skipped by Florida residents under age 65, says Gov. DeSantis

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    Can magnesium and vitamin D3 curb anxiety? Mental health experts weigh in on a viral TikTok claim

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    Arkansas toddler dies of rare brain-eating amoeba infection likely contracted at country club splash pad

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    NIH grants support Kessler Foundation scientists to advance research on neglect dyslexia and autism

    NIH grants support Kessler Foundation scientists to advance research on neglect dyslexia and autism

    Processing speed influences memory rehabilitation outcomes in TBI patients

    Processing speed influences memory rehabilitation outcomes in TBI patients

    Two more universities set to join IUCRC BRAIN at University of Houston to advance neurotechnology

    Two more universities set to join IUCRC BRAIN at University of Houston to advance neurotechnology

    New online course helps personal care assistants better understand spinal cord injury

    New online course helps personal care assistants better understand spinal cord injury

    New review looks at the impact of robotic exoskeletons on recovery of ambulation among individuals with acquired brain injury

    New review looks at the impact of robotic exoskeletons on recovery of ambulation among individuals with acquired brain injury

    Kessler Foundation researchers receive $1.7 million in grants to improve lives of TBI patients

    Kessler Foundation researchers receive $1.7 million in grants to improve lives of TBI patients

    Novel tool could help neuroscientists crack the secrets of spinal cord

    Novel tool could help neuroscientists crack the secrets of spinal cord

    Hypnosis offers new hope for people with spinal cord injury pain

    Hypnosis offers new hope for people with spinal cord injury pain

    Intelligent neuro-orthosis could benefit patients with limited hand function

    Intelligent neuro-orthosis could benefit patients with limited hand function

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    Boost brain health and slow mental aging with 10 intriguing tips from longevity experts

    Boost brain health and slow mental aging with 10 intriguing tips from longevity experts

    Aspartame could cause memory and learning deficits in future generations, a new study suggests

    Aspartame could cause memory and learning deficits in future generations, a new study suggests

    Dust at day care centers contained bacteria that could cause lung issues in kids, study found

    Dust at day care centers contained bacteria that could cause lung issues in kids, study found

    Ask a doc: ‘How can I make vaccinations and blood draws less scary for my child?’

    Ask a doc: ‘How can I make vaccinations and blood draws less scary for my child?’

    Abortion chatbot Charley helps women end their pregnancies: ‘Let’s get started’

    Abortion chatbot Charley helps women end their pregnancies: ‘Let’s get started’

    COVID vaccine just approved should be skipped by Florida residents under age 65, says Gov. DeSantis

    COVID vaccine just approved should be skipped by Florida residents under age 65, says Gov. DeSantis

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    Can magnesium and vitamin D3 curb anxiety? Mental health experts weigh in on a viral TikTok claim

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    ER visit times: Here’s how long patients spend in emergency rooms in each state

    Arkansas toddler dies of rare brain-eating amoeba infection likely contracted at country club splash pad

    Arkansas toddler dies of rare brain-eating amoeba infection likely contracted at country club splash pad

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Breakthrough bone cancer drug slows tumor growth, extends survival in early studies

admin by admin
March 15, 2023
in Health News
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Breakthrough bone cancer drug slows tumor growth, extends survival in early studies

For these affected by major bone most cancers — which is most cancers that originates within the bones — a promising new remedy could also be on the horizon.

The drug, known as CADD522, works by blocking a gene known as RUNX2, which is important to the method of bone formation in most cancers sufferers. 

In a latest research of mice, CADD522 considerably lowered tumor quantity, elevated survival and lowered cancer-induced bone illness — all with out surgical procedure.

MOST MEN DIAGNOSED WITH PROSTATE CANCER DON’T NEED TO RUSH TO SURGERY, RADIATION TREATMENTS: STUDY

The research, which appeared within the Journal of Bone Oncology, was led by the College of East Anglia in Norwich, England, together with researchers from the College of Sheffield, Newcastle College, the Royal Orthopaedic Hospital in Birmingham, and the Norfolk & Norwich College Hospital.

Lead researcher Dr. Darrell Inexperienced, a molecular biologist on the College of East Anglia, informed Fox Information Digital that there have been no new remedies for bone most cancers for 45 years. “This new drug, if permitted, could be the primary new drug in many years,” he mentioned in an electronic mail. 

Osteosarcoma, the most typical sort of bone most cancers, primarily impacts youngsters and younger adults. Of a promising new remedy, the lead researcher informed Fox Information Digital, “The drug solely assaults the most cancers cells and leaves the remainder of the physique alone.” (iStock)

Inexperienced mentioned that in preclinical trials, CADD522 resulted in a 50% enhance in survival charges for all foremost sorts of bone most cancers — with out chemotherapy or surgical procedure. 

He’s hopeful that survival could be additional improved with the addition of different remedies.

“Additionally, as a result of it’s a focused drugs, we’re but to watch uncomfortable side effects,” Inexperienced added. “The drug solely assaults the most cancers cells and leaves the remainder of the physique alone.”

FDA ISSUES NEW MAMMOGRAM REGULATIONS AIMED AT FURTHER BREAST CANCER PREVENTION

Inexperienced was impressed to review childhood bone most cancers after his greatest pal died from the illness as a young person.

“I hope that my work and the event of this new drug does him proud and carries his legacy eternally.”

“Ben’s greatest concern earlier than he handed away is that he could be forgotten,” Inexperienced informed Fox Information Digital. 

“I hope that my work and the event of this new drug does him proud and carries his legacy eternally, guaranteeing that he’s completely not forgotten.”

Extra analysis wanted, says oncologist

Dr. Susannah Cooper, a board-certified oncologist and hematologist at Arizona Oncology, reviewed the research however was not concerned within the analysis. She informed Fox Information Digital that the outcomes of those preliminary exams are promising.

There have been minimal advances in bone cancer treatments over the past four decades, doctors said — with one telling Fox News Digital,

There have been minimal advances in bone most cancers remedies over the previous 4 many years, docs mentioned — with one telling Fox Information Digital, “New remedy approaches are important in guaranteeing sufferers have the most effective outcomes.” (iStock)

“There are some cancers which have restricted response to standard remedies, and subsets of major bone most cancers are on this class,” Dr. Cooper mentioned in an electronic mail. 

“Because of this, there have been minimal advances of their survival prior to now 40 years. New remedy approaches are important in guaranteeing sufferers have the most effective outcomes.”

COLORECTAL CANCER IS SHOWING UP IN YOUNGER PEOPLE AND AT MORE ADVANCED STAGES: STUDY

Though Cooper is inspired by CADD522’s resulting in decreased tumors and improved survival in cell cultures and animal fashions, she identified that there’s nonetheless lots of analysis to be executed earlier than this drug will likely be used within the remedy of bone cancers.

The brand new drug resulted in a 50% enhance in survival charges for all foremost sorts of bone most cancers.

“Nevertheless, it does spotlight how understanding tumors at a molecular degree and creating drugs that particularly goal the genes liable for the onset and progress of most cancers can result in higher responses with fewer uncomfortable side effects,” Cooper mentioned. 

“This technique of drug growth has modified the form of most cancers care in recent times and is presently utilized in virtually all most cancers sorts.”

Up until this point, bone cancer treatments have mainly included high-dose chemotherapy and surgery.

Up till this level, bone most cancers remedies have primarily included high-dose chemotherapy and surgical procedure. (iStock)

Up till this level, bone most cancers remedies have primarily included high-dose chemotherapy — which might have important uncomfortable side effects — and surgical procedure, which generally entails amputation of the affected limb.

Inexperienced is hopeful that if his workforce obtains the required funding, they may have a medical trial for sufferers up and operating inside two to a few years.

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Osteosarcoma, the most typical sort of bone most cancers, primarily impacts youngsters and younger adults, the Mayo Clinic states on its web site.

CLICK HERE TO GET THE FOX NEWS APP

The American Most cancers Society estimates that about 3,970 new circumstances of bone most cancers will likely be identified in 2023. 

Round 2,140 individuals are anticipated to die from the illness this yr.

Melissa Rudy is well being editor and a member of the life-style workforce at Fox Information Digital. 

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