FRISCO, Texas, Nov. 5, 2025 /PRNewswire/ — 4WEB Medical, an orthopedic implant company focused on the development of innovative implants using its patented TRUSS Implant Technology™, announced the publication of a study conducted at the McKay Orthopedic Research Laboratory, Center for Musculoskeletal Disorders at the University of Pennsylvania. The study: Therapeutic Implants: Mechanobiological Enhancement of Osteogenic, Angiogenic and Myogenic Responses in Human Mesenchymal Stem Cells in 3D Printed Titanium Scaffolds has been approved for peer-reviewed publication in the journal Advanced Healthcare Materials (AHM), known for publishing research on high-impact materials, devices and technologies to improve human health.
“We are very pleased with the results of this study.” said 4WEB Founder and CEO Jessee Hunt. “The evolution of our Truss implant technology continues to gain momentum. The UPENN study demonstrates that the Truss implant maintains differentiation as the only therapeutic implant on the market. The structural mechanics of the truss design convert physiological loading into therapeutic tension at the surgical site, amplifying osteogenic activity. This therapeutic effect gives surgeons and their patients the best chance for success by providing continuous support while biological fusion takes place. Welcome to the era of therapeutic implants!”
The in vitro study appeared in the October issue of the journal AHM due to the important finding that orthopedic implants with advanced structural designs stimulate a therapeutic biological effect. Specifically, TRUSS Implant Technology provides a synergistic relationship between hierarchical surface roughness and macro truss architecture. The study demonstrated that, compared to surface roughness alone, the application of tension through a lattice element showed up to a 30% increase in osteogenic activity in the adhered cellular material.
Dr. Andrew Sama, co-director of HSS Spine in New York, commented: “The study conducted by UPENN on the 4WEB truss implant is the first I have seen in which the implant provides a therapeutic effect independent of chemical influence and beyond passive characteristics such as surface roughness.”
The company plans to build on this research with a series of additional studies that focus on reducing the high procedural costs associated with the use of BMPs and cellular biologics. 4WEB believes that studies will demonstrate that the therapeutic properties of TRUSS Implant technology, in combination with a cost-effective biologic graft material, will lead to a more cost-effective solution with faster fusion rates.
The study can be found online at: https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202501856
About UPENN McKay Orthopedic Research Laboratory
Dr. Robert Mauck co-directs the musculoskeletal regeneration program at the Penn Institute for Regenerative Medicine. His group focuses on musculoskeletal tissue engineering using rigorous mechanical and molecular analyzes to characterize the structure and function of native tissue and employs this information to improve the functional properties of engineered constructs through focused technology development. Specifically, this work employs adult mesenchymal stem cells, custom mechanobiological culture conditions, and novel cell scaffold technologies, and ranges from in vitro systems to large animal models. This work is supported by funding from the National Institutes of Health, the Department of Defense, the Department of Veterans Affairs, as well as several private foundations.
About 4WEB Medical
4WEB Medical, founded in 2008 in Dallas, TX, is an orthopedic implant company focused on the development of innovative implants utilizing its patented TRUSS Implant Technology™. 4WEB Medical was the first company to receive 510(k) clearance for an implant made with 3D printing technology. The company’s platform technology consists of armature-based implants that are designed to convert physiological loading into therapeutic tension at the surgical site, amplifying osteogenic activity and accelerating healing through their active participation throughout the healing process. The company’s proprietary designs have been used to produce a comprehensive offering of interbody implants for the cervical and lumbar spine, as well as implants for upper extremity, lower extremity, large joint and long bone procedures through its custom implant service that focuses on the individual needs of tumor and trauma patients with weak and deficient bone tissue or critical size defects.
SOURCE 4WEB Medical
